John Guill was born in 1840 in Kentucky to Russell Guill and Frances.

He married Narcissa Edell Falkner.

They were the parents of Alice Ann Guill, Thomas Jefferson Guill, George A Guill, Charles Alexander Guill, Flora Etta Guill, and Nannie Betty Guill.

He died in 1878 in Wingo, Kentucky.

Russell Guill sold property to the New Orleans & Ohio Railroad in Graves County, Kentucky on May 19, 1854.